'Sex is a biological reality, and it is not subordinate to subjective impressions, no matter how intense those impressions are, how sincerely they are held, or how painful they make facing the biological facts of life. No hormone injection or surgical mutilation is sufficient to change that...'

From Kevin Williamson, at National Review, "Laverne Cox Is Not a Woman":

The trans self-conception, if the autobiographical literature is any guide, is partly a feeling that one should be living one’s life as a member of the opposite sex and partly a delusion that one is in fact a member of the opposite sex at some level of reality that transcends the biological facts in question. There are many possible therapeutic responses to that condition, but the offer to amputate healthy organs in the service of a delusional tendency is the moral equivalent of meeting a man who believes he is Jesus and inquiring as to whether his insurance plan covers crucifixion.

This seems to me a very different sort of phenomenon from simple homosexuality (though, for the record, I believe that our neat little categories of sexual orientation are yet another substitution of the conceptual for the actual, human sexual behavior being more complex and varied than the rhetoric of sexual orientation can accommodate). The question of the status of gay people interacts with politics to the extent that it in some cases challenges existing family law, but homosexual acts as such seem to me a matter that is obviously, and almost by definition, private. The mass delusion that we are inculcating on the question of transgendered people is a different sort of matter, to the extent that it would impose on society at large an obligation — possibly a legal obligation under civil-rights law, one that already is emerging — to treat delusion as fact, or at the very least to agree to make subjective impressions superordinate to biological fact in matters both public and private.

Background at Boing Boing, "Transgender tipping point: Laverne Cox on the cover of TIME."